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What the Research Says About Muscle Loss on Ozempic Recent studies have measured how much lean body mass (which includes muscle) people lose while taking GLP-1 medications like Ozempic: A systematic review of 1,541 adults found that while semaglutide led to substantial fat loss, up to ~40% of the weight lost came from lean mass in some trials ( PubMed )
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Trends will continue, as they always do
Mol Pharm 22:11001109
The recent research also found that although persistence among the 45 percent of the population using weekly-dosed semaglutide (Ozempic and Wegovy ) was somewhat better, still only 1 in 4 of those initiating semaglutide treatment for obesity remained on GLP-1 therapy at two years
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