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[57] Concurrently, semaglutide inhibits the release of glucagon from pancreatic alpha cell, which decreases glucose production by the liver (gluconeogenesis) and maintains blood sugar level stability, particularly preventing sharp spikes after meals

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Beyond pharmacotherapy, bariatric surgery remains the most effective intervention for severe obesity (BMI 40 kg/m or 35 kg/m with comorbidities), producing sustained weight loss of 2030% and significant improvements in obesity-related conditions

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