See a local weight loss physician about less expensive alternatives or compounded generic semaglutide
Wang, L., Xu, R., Kaelber, D
Combining with DPP-4 inhibitors is generally not recommended, as both drug classes work on the incretin system Adding basal insulin for those with more significant hyperglycaemia, which can be used alongside GLP-1 medications (with careful monitoring for hypoglycaemia) Switching to insulin therapy entirely may be necessary for those with advanced beta cell failure For weight management , when GLP-1 medications don't produce adequate weight loss, alternatives include: Orlistat , a lipase inhibitor that reduces fat absorption, though weight loss is typically modest (2-3 kg on average) Naltrexone-bupropion (Mysimba), which works on appetite centres through different pathways
Matarrelli, B., Vitacolonna, E., D'Angelo, M., Pavone, G., Mattei, P
& Schlessinger, A
2020;76 Suppl 1:63-64