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Currently, CAR-T therapy has demonstrated significant clinical efficacy, and the FDA has approved seven products for the treatment of hematological malignancies: Kymriah, a CD19-specific CAR-T product, was the first to be approved on August 31, 2017, for treating patients with refractory or relapsed B-cell precursor acute lymphoblastic leukemia (B-ALL) (38)

Proc Nat Acad Sci USA 99:511516

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The consequent impairment in oxalate homeostasis can trigger localized and systemic inflammation, progressive kidney disease and cardiovascular complications, including sudden cardiac death

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