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The most common treatment-emergent adverse events were gastrointestinal, and the majority were of mild to moderate severity and resolved by the end of the study

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This includes eligibility screening, dose titration, a critical phase in tirzepatide therapy where doses advance from the 2.5 mg starting dose through escalating levels (5 mg, 7.5 mg, 10 mg, and 12.5 mg or 15 mg), and ongoing monitoring of metabolic and clinical outcomes

The increasing demand for GLP-1s has significant cost implications for employer plan sponsors

But he was also cautious about whether TB-500 at that level was correct, given the different dosing needs of each compound