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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

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The intact rat pancreas's GIP perfusion only stimulates glucagon secretion at low glucose levels (4.4 mM) and not at postprandial glucose concentrations (8.9 mM), suggesting that GIP receptor activity in the cell appears to be glucose dependent [18]

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Based on the predominant stool type, assessed with the Bristol stool form scale (BSFS) (Lewis and Heaton, 1997), IBS patients can be categorized into four subgroups: IBS with predominant constipation (IBS-C), IBS with predominant diarrhea (IBS-D), IBS with mixed bowel habits (IBS-M), and unclassified IBS (IBS-U) (Lacy et al., 2016)

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