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The use of any prescribed or over-the-counter medications, supplements, caffeine, cannabis, or alcohol should be noted

It is still a useful benchmark: compare it against the measurement error of reading 2.5 units on a U-100 syringe, where a single unit misread at 10 mg/mL is a 40% error on a 0.25 mg step

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Goodman clarifies

Can usually walk with discomfort