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Dosing is 600-1200mg daily for severe cases or 300-600mg daily for maintenance, as determined by a healthcare professional

i , In vitro binding assay showed Smurf1 Y439A and R660A mutants inhibited the Smurf1-SMART1-CRBN complex formation (1 M SMART1)

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The main difference is how its formulated

Step 5: Position the pen