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Proper selection ensures effective results, minimal side effects, and safer overall outcomes
Abbreviations: AUC: area under the curve
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Bulking agents containing ispaghula may help regulate stool consistency
The mechanism of action includes several key effects: Stimulating insulin secretion from the pancreas in a glucose-dependent manner, helping to control blood sugar levels Slowing gastric emptying , which prolongs the feeling of fullness after meals Reducing appetite through effects on brain centres that regulate hunger Decreasing glucagon secretion , which helps prevent excessive glucose production by the liver By targeting these multiple pathways, GLP-1 medications can lead to significant weight loss when combined with lifestyle modifications
Tirzepatide (Mounjaro) : A newer entry in the GLP-1 category, tirzepatide has shown promising results in clinical trials, leading to substantial weight loss and improved metabolic markers
