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[1] [4] If swelling occurs while taking a GLP-1 agonist, it is important to consider alternative explanations, including: Concurrent medications (e.g., calcium channel blockers, NSAIDs) Underlying cardiac, renal, or hepatic conditions Dietary changes or increased salt intake Venous insufficiency or lymphatic issues Patients experiencing unexplained swelling should not automatically attribute it to their GLP-1 medication without proper clinical assessment, as other potentially serious causes must be excluded

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