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Koska J, Migrino RQ, Chan KC, Cooper-Cox K, Reaven PD
FDA , 4:25-cv-00174 (N.D
Gradual dose escalation can significantly mitigate the frequency and severity of symptoms such as nausea and diarrhea, as it allows patients to adapt to therapy over time (Huang et al., 2025
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For renal safety, Rybelsus can be used in patients with an eGFR greater than 30 mL/min, while metformin is contraindicated when eGFR drops below 30 and requires dose reduction between 30-45 mL/min
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