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The failure of both Pfizer oral GLP-1 candidates underscored the difficulty of the small-molecule approach and left orforglipron as the only advanced oral non-peptide GLP-1 agonist in clinical development

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Mucosal changes like sore tongue, mouth ulcers, or glossitis are also common with vitamin B12 deficiency

Consistent with these reports, previous lineage tracing of Nestin + MSCs in vivo revealed a relatively quiescent state in adult mice as minimal GFP positive cells could be identified one month after induction, whereas abundant GFP expression was detected 8 months after induction (27)