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Results announced December 2025: participants on 12mg retatrutide lost an average of 28.7% of their body weight , versus 2.1% on placebo
In Phase 3 trials, CagriSema achieved 20-22% average weight losssignificantly more than either component alone
Pearson-Smith & Patel, 2017
Kim, D., Hwang, J.F.H., and Fendrick, A.M., Balancing innovation and affordability in anti-obesity medications: the role of an alternative weight-maintenance program, Health Affairs Scholar , May 2, 2024
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To enable self-delivery into mammalian cells, we reconstitute evolved proteases with a native BoNT translocation domain, selectively killing cultured cancer cells while sparing non-cancerous cells
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