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Researchers who consistently inject near the injury report faster and more complete outcomes than those using distant injection sites

Br J Dermatol 2006;155(1):39-49

EClinicalMedicine, 73, 102661

Z.KaurH.ThorekD

However, the sample available at the 6-year follow-up was not entirely comparable to the one selected for the main analyses, as it included subjects with a substantially better health profile (indicative of survival bias) compared to those lost to follow-up

For this reason, research protocols have excluded subjects with: Uncontrolled hypertension Established cardiovascular disease History of myocardial infarction or stroke The cardiovascular monitoring protocol used in FDA approval trials required blood pressure measurement before and after administration, establishing a safety baseline that researchers in any context should consider