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"I knew that admitting to being on medication was going to be a big freaking deal," says Winfrey in PEOPLE's new cover story

Your Turn The GLP-1 thickets are here

A subsequent study confirmed that heterologous expression of P9 increases GLP-1 secretion from intestinal L cells in a dose-dependent manner

Caution notes If you have kidney disease or have been told to limit protein for medical reasons, check with your healthcare provider before increasing intake significantly

Ill be honest, I definitely would have been tempted to ask my doctor about using them

[11] Without doctor oversight, lab work, or personalized care, these risks go unchecked