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Disruptions in this fragile equilibrium lead to metabolic and gastrointestinal diseases, highlighting the profound impact of the gut microbiota on the host intestinal metabolic processes

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Proc Natl Acad Sci U S A 107(11):52085213

Baseline HbA1c was 7.9%, mean diabetes duration 2.5 years, mean BMI 35.8

Permanent effects are uncommon but can occur with rare serious events (acute pancreatitis with complications, gallbladder removal after gallstones, or rare kidney injury that does not fully recover)