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Methods We performed an updated meta-analysis of randomised, placebo-controlled studies of semaglutide therapy that report acute pancreatitis

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These symptoms are dose-dependent and typically occur at intakes exceeding 10 to 15 grams per serving, particularly in individuals unaccustomed to consuming this sweetener

They are consistent with the known side effect profile of GLP-1 receptor agonists already approved in the UK (see, for example, the Wegovy Summary of Product Characteristics, available via the electronic Medicines Compendium)