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Interestingly, the strong dependence of mitochondrial -oxidation on autophagic and fatty acid (FA) catabolic processes makes some tumors more resistant to nutrient deprivation and environmental stressors 13
Indeed, superoxide can undergo dismutation to H 2 O 2 , a mild oxidant that can be converted to the highly reactive hydroxyl radical in the presence of transition metals (Fe 2 + , Cu + ) by means of the Fenton reaction
Gastrointestinal side-effects are common on metformin initiation, but are usually transient, and can be managed by a series of preventative measures outlined below
Mol Metab (2021) 51:101241
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