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Structural abnormalities of the BBB in CNS disease When multiple CNS diseases (such as Alzheimer's disease, multiple sclerosis, and stroke) occur, the resulting pathological responses (including inflammation, lipid peroxidation, and excitotoxicity) destabilize the BBB, leading to its dysfunction[38, 39]
Human controlled trial data is still absent, so confidence is low
FurukawaSSaitoHInoueTMatsudaTFukatsuKHanIet al
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(4) Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ
However, smoking specifically increases the risk of breast cancer by upregulating the CYP1B1 and CYP1A1 enzymes
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