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Notably, L2HG-induced ferroptosis occurs independently of impaired cystine uptake, transsulfuration pathway activity, or increased GPX4-mediated GSH utilization, revealing a non-canonical ferroptosis mechanism driven by enhanced GSH catabolism
Its selectivity profile makes it a valuable tool compound for dissecting the ghrelin/GHS axis in endocrine research settings
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Target Synonyms: L-Reduced Glutathione
J Plant Physiol 165(6):600611
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