This is due to low absorption in the intestine, and breakdown by enzyme activity
Boosting the production of structural Collagen I, III, and IV

Ingredients : Water, Ethylhexyl Methoxycinnamate, Butylene Glycol, Ethylhexyl Salicylate, Octocrylene, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Butyl Methoxydibenzoylmethane, Dipropylene Glycol, Niacinamide (20,000ppm), Squalane, C14-22 Alcohols, 1,2-Hexanediol, Polyglyceryl-2 Stearate, Propanediol, Hydroxyacetophenone, Glyceryl Stearate, Stearyl Alcohol, C12-20 Alkyl Glucoside, Tromethamine, Centella Asiatica Extract (1,510ppm), Carbomer, Melaleuca Alternifolia (Tea Tree) Extract, Hippophae Rhamnoides Fruit Extract, Vitis Vinifera (Grape) Fruit Extract, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Uncaria Sinensis Extract, Glycerin, Adenosine, Disodium EDTA, Oryza Sativa (Rice) Bran Extract, Hydrogenated Phosphatidylcholine, Caprylic/Capric Triglyceride, Sodium Hyaluronate, Glucose, Hydrolyzed Collagen, Sucrose Stearate, Glutathione (10ppm), Cyclodextrin, Cetearyl Alcohol, Caprylyl Glycol, Beta-Glucan, Caprylhydroxamic Acid, Ethylhexylglycerin, Asiatic Acid, Asiaticoside, Madecassic Acid, Madecassoside, Tropolone, Hyaluronic Acid, Potassium Hyaluronate

This is within the typical range for rapid weight loss but better than what is seen with some less sophisticated approaches
Effects of exogenous melatonin and glutathione on zinc toxicity in safflower ( Carthamus tinctorius L.) seedlings
Endocrinology (2001) 4