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NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict
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MOTS-c activates the same AMPK pathway physical activity triggers, better insulin sensitivity, more mitochondria, more metabolic flexibility, so your workouts and nutrition actually produce the results they should
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