The NF-B signaling pathway, which is an essential mediator of inflammation, immune response, and cell survival, is frequently dysregulated in HCC, leading to tumor development and chemo-resistance [104]
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5 : 473476 Chandrasekaran K, Hatanpaa K, Brady DR, Rapoport SI
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The mechanism is dose-dependent sympathetic nervous system activation: GH release stimulates lipolysis and thermogenesis, elevating core body temperature and triggering mild adrenergic arousal that conflicts with sleep onset
Administration of the infusion over a period determined by the treatment plan