Transport of glutamate and other amino acids at the blood-brain barrier
For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101
acknowledges support from the NIH (R01DK107007), the US Department of Veterans Affairs (101RX001030), the Diabetes Action Research and Education Foundation and the Baltimore Geriatric Research Education and Clinical Center (GRECC)
Severe injuries or post-surgical recovery may benefit from longer courses, while acute injuries might respond well to shorter intensive protocols
Telomere dysfunction induces metabolic and mitochondrial compromise
This mechanism has been validated in RCTs in populations including older adults, hemodialysis patients, and schizophrenia patients on maintenance medication