DOI: Published online: September 26, 2023 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea 2 Division of Endocrinology and Metabolism, Department of Internal Medicine, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Korea 3 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea 4 Department of Endocrinology and Metabolism, College of Medicine, Kyung Hee University, Seoul, Korea 5 Department of Endocrinology and Metabolism, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea 6 Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea 7 Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea 8 Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St

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Extended 15-year follow-up studies showed that treatment prevented age-related impairment of physical endurance, normalized circadian rhythm of melatonin production, and improved carbohydrate and lipid metabolism markers
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heart rate and blood pressure should be monitored in patients with pre-existing cardiovascular disease
The result is accelerated tooth decay, particularly along the gum line and between teeth