downsides to glp 1 GLP-1 Agonists For Obesity In Non-Diabetic Patients: Game Changer Or Overhyped? A Critical Analysis GlobalRPH Mapping the effectiveness and risks

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Multiple randomized controlled trials demonstrate that GLP-1 receptor agonists produce 15-22% average body weight loss over 68 weeks, with cardiovascular benefits including reduced blood pressure and improved metabolic markers

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A large multinational cohort study spanning three countries, alongside another randomized controlled trial, both concluded that GLP-1RAs usage was not associated with a significant increase in thyroid cancer risk [2, 5]