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Both healthcare professionals and members of the public can submit reports via the Yellow Card website (yellowcard.mhra.gov.uk) or through the Yellow Card app

Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]

N Engl J Med 359(23):24562467 Cleland JGF, Tendera M, Adamus J, Freemantle N, Polonski L, Taylor J et al (2006) The perindopril in elderly people with chronic heart failure (PEP-CHF) study

14 June 2009

Less than 3% of VPA is excreted unchanged in the urine [10, 14, 15], much of which is in the form of valproylcarnitine [27, 28]

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