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Similar results were observed in an experiment involving a germ-free mouse strain, where the animals transplanted with microbiome isolated from depressed patients showed an increase in immobility time in the forced swim test and a decreased proportion of central motion distance in the open field test, compared to mice transplanted with bacteria obtained from healthy control subjects [101]
Patients taking insulin and insulin secretagogues: consider decreasing the dose of these medications when starting tirzepatide
Research suggests that individuals with type 2 diabetes may have reduced GLP-1 secretion or diminished incretin effect compared to those without diabetes, though this finding is not universal across all studies
Naunyn-Schmiedeberg's Arch Pharmacol
In clinical practice it has been largely superseded by once-weekly semaglutide, though it remains a licensed option
A., Britt, E
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