The current evidence base is phase 2 data, which is why retatrutide is investigational and why physician supervision is a clinical requirement rather than a formality
The table below organizes the practical differences
For individuals with sensitive stomachs, taking tablets with a small amount of water or immediately before a light meal may help prevent any digestive discomfort
Rubino D, Abrahamsson N, Davies M, Hesse D, Greenway FL, Jesen C, et al
GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells
Segar notes, Many of these interactions are based on mechanistic data, animal data, and isolated case reports. This means that many of the potential interactions in the list above havent been confirmed in human studies