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Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study

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Short answer: It appears tolerable in very limited early human data, but there is not enough evidence to call it safe for general use

Of the surveyed propolis ointment group, 81.8% judged their treatment to be very effective compared to 60% of the placebo group finding the ointment hardly effective. 8 Utilizing propolis in conjunction with acyclovir has been shown to synergistically suppress HSV-1/-2 recurrence over acyclovir alone