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Mechanistically, GLP-1RAs inhibit the activation of hepatic stellate cells (HSCs), which are the principal fibrogenic cell type in the liver

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Exenatide could promote the increase of Treg cells in mice, but inhibit the tissue infiltration of Th17 cells, suggesting that exenatide exerts immunomodulatory effects by correcting Th17/Treg imbalance (87)

Other Macular Complications Additionally, a small number of patients taking GLP-1 agonists like semaglutide have developed macular edema, a build-up of fluid in the macula, an area in the center of the retina responsible for sharp, straight-ahead vision

Other common systemic side effects include constipation, diarrhea, headache, and fatigue

Managing nausea doesn't reduce efficacy