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This broader mechanism may explain why retatrutide has shown especially strong weight loss results in early trials, though semaglutide currently has the advantage of regulatory approval and longer-term real-world data

SCENIC regulon activity, scDRS-derived AD enrichment scores and Class C AD module scores were modeled with linear mixed-effects models including mouse identity and sequencing pool as random effects, followed by two-sided lsmeans t -tests with BH correction

The escalation pattern starting at 2mg regardless of target dose is consistent across all arms above 1mg

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