Another study developed phasetransitional Pt (IV) NPcRGD nanoparticles with a hybrid lipidpolymer shell for ovarian cancer, which are both GSHsensitive and ultrasoundresponsive, demonstrating enhanced therapeutic efficacy and reduced side effects in in vivo models [121]
Their isotope-labeling derivatization-LC-MS/MS method demonstrated excellent linearity, high precision (intra-day CVs 7.8 %, inter-day CVs 8.8 %), and accuracy (recoveries between 86.9 %-109.7 %)
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Upon reaching the tumor site, stealth liposomes primarily remain within the extracellular matrix rather than entering tumor cells directly
Third, by skipping the whole production of GSH and supplement the final product