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In conclusion, multi-targeted nanomedicine delivery systems hold strong preclinical potential to provide a novel framework for advancing osteosarcoma treatment by precisely modulating the TME and eliciting durable antitumor immune responses
The linear regression analysis is therefore certainly valid in attaining the standard redox potential
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Methods Participants This study was conducted in accordance to the Declaration of Helsinki, and the protocol was approved by the ethics committee of the Gunma University Graduate School of Medicine (Approval number HS2018-140)
However, not only does p62 prevent NRF2 binding to KEAP1, it induces autophagic degradation of KEAP1, resulting in a positive feedback loop of NRF2 activation [82]
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