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Brewed teas may also contain significant amounts of heavy metal contamination (Schwalfenberg et al , 2013), this may account for some of the effects noted in the above stated studies

PMID: 16484611 DOI: 10.1161/01.RES.0000214553.37930.3e Fitzgerald DJ, FitzGerald GA (2013): Historical lessons in translational medicine

Lee CA, Lillibridge JH, Nelson SD, Slattery JT: Effects of caffeine and theophylline on acetaminophen pharmacokinetics: P450 inhibition and activation

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Constipation Constipation ranks as the second most commonly reported GI side effect