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In that study, the glucose-sensing transcription factor carbohydrate response element binding protein (ChREBP) has been shown to initiate a regulatory program driving an early transcriptional activation of metabolic genes, which is followed by a second wave of transcriptional regulation wherein cell-cycle genes are activated and -cell identity genes are repressed
Spiking costs paired with increasing demand and indications that GLP-1s need to be taken for a good amount of time to be effective are creating an onerous challenge for many employers
Based on the pilot study findings, final adjustments were made to the survey instrument to enhance its reliability and validity
Higgins JP, Green S
Pharmaceutical Research (1999) 7
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