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Thrombospondin-1 (TSP1) has been shown to upregulate PD-L1 expression in osteosarcoma through activation of the STAT3 pathway, thereby impairing antitumor immunity (37)

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It should not be interpreted as evidence that one medication is more effective or appropriate than another

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Manufacturers making bulk product face a different set of requirements: They must register with FDA and have a valid COA