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2.2.1 Oxidative stress and mitochondrial dysfunction METH significantly increases the production of ROS and reactive nitrogen species, overwhelming antioxidant defenses in neurons

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The collagen-building response peaked at 1 nanomolar

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Journal of Investigative Dermatology

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Cellular-level changes are measured through validated biomarkers when available

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Compromised skin is more vulnerable to UV damage and post-inflammatory pigmentation

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specific tendinopathy), validated biomarkers and functional outcomes, long term safety and immunogenicity surveillance, and pharmacovigilance for angiogenesis related adverse events

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