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On the other hand, Akkermansia muciniphila can activate immune cells in the intestine, such as macrophages and dendritic cells, to secrete the anti-inflammatory cytokine IL-10 and inhibit the inflammatory response (Mei et al., 2024)
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Thus, Prx1 hyperoxidation is not a digital allornothing switch but rather an analog switch, implying that hyperoxidation of even a fraction of Prx1 may be beneficial for cell survival and therefore arguing strongly in favor of the physiological relevance of this mechanism
