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Molecular Biology of the Cell, 20 (5), 14541463
Now, they have been compared head-to-head in a trial, where 751 overweight, nondiabetic adults were randomized to Zepbound (target dose 10 mg or 15 mg/week) or Wegovy (target dose of 1.7 mg or 2.4 mg/week)
This unique mechanism of action sets retatrutide apart from traditional weight loss drugs such as semaglutide (Wegovy) as it aims to target all three of these key hormones involved in glucose (blood sugar levels) and satiety regulation
Suggested titration for sensitive individuals: Increase dose only if the current dose is well-tolerated
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