Pharmacological Selectivity: Minimal impact on ACTH, cortisol, prolactin, FSH, LH, or TSH, distinguishing it from less selective GHRPs
Patch delivery systems GLP-1 patches like Onmorlo represent another delivery method that will change dosing entirely
Tirzepatide frequently causes nausea, vomiting, diarrhea, and decreased appetite, particularly during dose initiation and escalation
It also covers a family history of familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, or a first-degree relative (parent, sibling, or child) diagnosed with colorectal cancer or an adenomatous polyp
Much longer and the medication might accumulate excessively or take too long to clear
Retatrutide: promising, powerful, and next-generation potentially offering deeper fat-loss and metabolic effects, for those open to advanced therapy under close supervision