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Author contributions JX: Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing original draft

Regarding plasma B12 - this is not the case, serum B12 often remains highly elevated (well over the normal range) even while symptoms return - this is why testing B12 once treatment begins is not recommended

Incorporating and interpreting regulatory guidance on estimands in diabetes clinical trials: the PIONEER 1 randomized clinical trial as an example

In addition, histopathology was conducted at 24 mo of age or end of life, as described below

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Purpose The purpose of our Vitamin B12 Shot is to improve energy levels, boost metabolism, help burn fat and aid in deficiency