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Many practitioners combine both routes for comprehensive coverage

Most microdose protocols circulating online have not been studied in randomized trials, and broader claims around inflammation, cognition, longevity, or optimization are largely extrapolated from studies about full doses

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Lancet Psychiatry 2021;8(10):883-91 Rahman T et al

What it does not justify is casual, unsupervised use of a compound whose long-term human safety profile is still being written