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Nonetheless, several groups should be considered at elevated risk and would generally be advised against use outside a controlled clinical trial
it's a strategic decision about your research methodology
Knapen MHJ, Drummen NE, Smit E, et al
Every case from arm I was matched for gender, age (1 year range was allowed between the selected patients), and BMI Z score (1 SD range was allowed between them) with a patient from arm II to serve as controls
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