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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

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That enzyme name sounds technical, but its role in fat metabolism is surprisingly straightforward once you understand it

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Defyne can be used most anywhere on the face - but here at Reflections our physicians find Defyne creates the most natural results when used for the Nasolabial Folds, and when indicated, as a layering filler (over something stiffer like Voluma or Restylane Lyft) in the cheeks and chin