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SURMOUNT-5, the first head-to-head trial (published in NEJM, 2025), found tirzepatide produced about 20.2% average weight loss versus 13.7% for semaglutide over 72 weeks
Click here to listen to this article Share via If youre on a GLP-1 medication like Ozempic, Wegovy, Mounjaro, semaglutide, or tirzepatide, your scale is likely moving, but are you really tracking what matters
Additionally, GLP-1s helps the body burn fat while maintaining muscle mass and hydration
Provider response delays: If the insurance company asks for additional information, the healthcare provider's response to the insurer can extend the approval timeline
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