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Patients with GATM deficiencies have milder clinical manifestations which are generally limited to moderate intellectual disability and language disorder

Cysteine contains sulfur

Using 3.0 mL (1.67 mg/mL) is also acceptable but requires larger syringes at higher doses

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Many patients experience measurable improvements in fasting insulin levels and HOMA-IR scoresa standard marker of insulin resistancewithin 8 to 12 weeks of consistent GLP-1 treatment

Hypothyroid patients on thyroid replacement therapy are generally safe candidates, but their endocrinologist should be notified of GLP-1 treatment initiation so TSH monitoring can be adjusted as needed