Combination dosing should be derived from published protocols appropriate to your species, model, and endpoints
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According to some publications, the extent and the intensity of physiological oral mucosal melanin hyperpigmentation increase with age probably owing to the cumulative effects of endogenous and extrinsic melanogenic stimuli, such as inflammatory processes, drugs, tobacco smoke, and recurrent minor functional injuries [4, 6, 11, 13]
(2016) 40:169970610.1038/ijo.2016.121 95
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In those situations, lowering the dose may temporarily reduce symptoms, but it does not address the underlying sleep disruption that is contributing to the problem