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Tingling or flushing with very high doses of B3 or B6 (uncommon in clinical settings with proper dosing)

A patient who stabilizes at 5 mg with steady laboratory results and reasonable appetite control should not be pushed to 15 mg solely to gain a few extra pounds, especially if higher doses cause gastrointestinal trouble or interfere with daily life

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The peptide safety and risks article covers the full spectrum of safety considerations, from sterile technique to recognizing adverse reactions

Side effects are one contributing factor with respect to discontinuation

The stability of transition-metal complexes