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Indeed, eGFR values were greater in patients on tirzepatide compared to those on insulin glargine, with a mean eGFR decline rate of 1.4 ml/min/1.73 m 2 per year in tirzepatide users and a between-group difference in eGFR reduction of 2.2 ml/min/1.73 m 2 per year [49]
The research project was approved by our institution (Universidad Complutense de Madrid) and by the "Real Federacin Hpica Espaola"
Concordantly, GLP-1 RA exposures reported to poison control centers have increased dramatically in recent years from 241 single substance exposures in 2016, the first year the class was recorded separately in the National Poison Data System, to 2170 exposures in 2022 [4, 5]
Taken together with the observation of elevated lipase concentrations in patients treated with GLP-1 receptor agonists [9], it is conceivable that these drugs exert some effects on the exocrine pancreas, although a specific mechanism of action has not yet been identified, and the presence of GLP-1 receptors in pancreatic exocrine cells is still a matter of dispute [10]
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muciniphila and metabolic phenotypes: OGTT AUC (oral glucose tolerance test area under the curve), iBAT temp (interscapular brown adipose tissue temperature), and GLP-1 (plasma glucagon-like peptide-1 concentration)
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